{ "schema_version": 1, "kind": "condition", "id": "asymptomatic-bacteriuria", "name": "Asymptomatic Bacteriuria (Pregnancy)", "category": "infectious", "sources": "Egyptian National Drug Formulary - Antimicrobial 2023 · Monuril 3g granules for oral solution SmPC sections 4.1-4.2 (eMC product 7329) · UTI and asymptomatic bacteriuria in pregnancy - disease-level clinical article (uti-in-pregnancy-full.txt)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 · Monuril 3g granules for oral solution SmPC sections 4.1-4.2 (eMC product 7329) · UTI and asymptomatic bacteriuria in pregnancy - disease-level clinical article (uti-in-pregnancy-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 218, "generic": "Nitrofurantoin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice daily (modified-release) for 7 days in pregnant women with positive screening urine culture", "adult_duration": "7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "Urinary antiseptic that concentrates in the urine to clear asymptomatic bacteriuria in pregnancy; treating it matters because, left alone, it raises the risk of pyelonephritis and preterm labor. Avoided close to delivery for the reason already noted in the cautions.", "cautions": [ "Screening and treating asymptomatic bacteriuria is indicated ONLY in PREGNANT WOMEN and prior to traumatic urological procedures.", "CONTRAINDICATED at term (36-42 weeks pregnancy) due to risk of neonatal hemolytic anemia.", "Avoid in renal impairment (eGFR <45 mL/min)." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not indicated for routine screening outside pregnancy", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "COLIFURAN 100 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 2.4, "pack_count": 20, "unit_price": 0.12, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UVAMINE RETARD 100 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > ACINO", "price_egp": 47.0, "pack_count": 20, "unit_price": 2.35, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEPAFURAN 100 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 54.0, "pack_count": 20, "unit_price": 2.7, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MACROFURAN 100 MG 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 82.0, "pack_count": 30, "unit_price": 2.73, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "asymptomatic-bacteriuria" }, { "id": 219, "generic": "Amoxicillin + Clavulanic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 625.0, "adult_dose": "500/125 mg three times daily (or 875/125 mg twice daily)", "adult_duration": "7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "Broad-spectrum penicillin and beta-lactamase inhibitor combination used as an alternative to nitrofurantoin for asymptomatic bacteriuria in pregnancy, chosen when nitrofurantoin is unsuitable or culture sensitivities favor it; the formulary rates it Pregnancy Risk Factor B.", "cautions": [ "The Egyptian formulary rates it Pregnancy Risk Factor B and says nothing about individual trimesters. On breastfeeding it is specific: amoxicillin/clavulanate may be used while breastfeeding, with care, at the doses usually recommended, and the infant watched for gastrointestinal upset - thrush and diarrhoea in particular.", "Check urine culture sensitivity results." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist indication only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AUJED 625 MG 12 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC > JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 19.2, "pack_count": 12, "unit_price": 1.6, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "E-MOXCLAV 625MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEXICLAVE 625 MG 12 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOVELL PHARMA", "price_egp": 37.5, "pack_count": 12, "unit_price": 3.12, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAGNABIOTIC 625MG 8 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 37.0, "pack_count": 8, "unit_price": 4.62, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVIMOX 625 MG 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 107.0, "pack_count": 12, "unit_price": 8.92, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CURAM 625MG 12 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ > NOVARTIS", "price_egp": 108.0, "pack_count": 12, "unit_price": 9.0, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGMENTIN 625 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 117.0, "pack_count": 10, "unit_price": 11.7, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVOCILLIN 625 MG 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ORGANOPHARMA", "price_egp": 31.5, "pack_count": null, "unit_price": null, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 156.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "asymptomatic-bacteriuria" }, { "id": 220, "generic": "Fosfomycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 3000.0, "adult_dose": "Fosfomycin 3 g orally once. Dissolve the sachet in a glass of water and take it immediately, on an empty stomach - about 2-3 hours before or after a meal - preferably before bedtime and after emptying the bladder.", "adult_duration": "single dose", "dose_source": "UTI and asymptomatic bacteriuria in pregnancy - disease-level clinical article (uti-in-pregnancy-full.txt)", "rationale": "Urinary antiseptic valued in pregnancy for how simple the course is to complete, making it a useful alternative to nitrofurantoin or amoxicillin-clavulanate when finishing a longer antibiotic course is a concern.", "cautions": [ "The Monuril label's own indications are acute uncomplicated cystitis and prostate-biopsy prophylaxis; it does not name asymptomatic bacteriuria. The indication and the 3 g single dose come from the pregnancy UTI article, and the label supplies only how to take the sachet.", "Not recommended by the label in renal impairment with creatinine clearance below 10 ml/min.", "Fosfomycin is a reasonable option for asymptomatic bacteriuria, though it may be less effective for cystitis than a multi-day regimen.", "The label does not say it is safe in pregnancy - it says Monuril \"should only be used during pregnancy, if clearly necessary\" ( PHARMACON", "price_egp": 293.0, "pack_count": null, "unit_price": null, "strength_mg": 3000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "asymptomatic-bacteriuria" } ] }