{
  "schema_version": 1,
  "kind": "condition",
  "id": "anhidrosis",
  "name": "Anhidrosis (absent sweating)",
  "category": "chronic",
  "sources": "Anhidrosis - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK555988/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class SD73.00 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care · Anhidrosis (absent sweating) - disease-level clinical article (anhidrosis-full.txt)",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care · Anhidrosis (absent sweating) - disease-level clinical article (anhidrosis-clinical.txt) · Anhidrosis (absent sweating) - disease-level clinical article (anhidrosis-full.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 185,
      "generic": "Stop the cause, keep the patient cool (Recognition & Referral)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Reduced or absent sweating - uncommon as a presenting complaint and dangerous in Egypt's heat. The management is causal and physical, not pharmacological. Treating whatever underlies it is the cornerstone, the article's own example being a lung carcinoma that has produced a Horner syndrome and with it the anhidrosis. Where no offending agent can be stopped, it warns that there may be little else to offer, and that keeping the patient in a cool environment has to be pressed hard. The practical measures it gives are a water spray bottle for cooling, and - where the sweat glands are blocked - exfoliating often and gently. Review the drug list for an anticholinergic cause, and refer for the neurological or dermatological cause.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Reduced or absent sweating - uncommon as a presenting complaint and dangerous in Egypt's heat. The management is causal and physical, not pharmacological. Treating whatever underlies it is the cornerstone, the article's own example being a lung carcinoma that has produced a Horner syndrome and with it the anhidrosis. Where no offending agent can be stopped, it warns that there may be little else to offer, and that keeping the patient in a cool environment has to be pressed hard. The practical measures it gives are a water spray bottle for cooling, and - where the sweat glands are blocked - exfoliating often and gently. Review the drug list for an anticholinergic cause, and refer for the neurological or dermatological cause.",
      "cautions": [
        "Heat intolerance and risk of heat stroke in a hot climate; generalised anhidrosis needs urgent evaluation to prevent hyperthermia.",
        "RED FLAG - Children with anhidrosis are at particularly higher risk of heat-related illness because their core body temperature rises faster and their heat-loss mechanisms are less efficient.",
        "No drug row is listed here. The article names exactly one drug class, for one rare subtype, with no drug, no dose and an explicit caveat about the evidence: it acknowledges that nothing substantial supports corticosteroids, while noting that many case reports still advise giving them early in AIGA. (AIGA is acquired idiopathic generalised anhidrosis, a dermatology diagnosis.) And the window closes - once treatment is delayed, or the sweat glands have already been destroyed, corticosteroids may then be of no benefit. That decision belongs to the dermatologist who makes the AIGA diagnosis."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "anhidrosis"
    }
  ]
}