{ "schema_version": 1, "kind": "condition", "id": "angular-cheilitis", "name": "Angular cheilitis (stomatitis)", "category": "infectious", "sources": "NICE CKS Angular Cheilitis · Egyptian National Drug Formulary - Antimicrobial 2023 (fusidic acid monograph) · Daktarin Sugar Free 2% Oral Gel SmPC sections 4.2-4.5 (eMC product 6597)", "review_status": "reviewed", "verified_against": "Daktarin Sugar Free 2% Oral Gel SmPC sections 4.2-4.5 (eMC product 6597) · Egyptian National Drug Formulary - Antimicrobial 2023 (fusidic acid monograph) · Angular Cheilitis - disease-level clinical article (angular-cheilitis-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 182, "generic": "Miconazole", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 2% oral gel thin layer to labial commissures 4 times daily after meals, continuing for at least a week after symptoms disappear", "adult_duration": "10-14 days, continuing for a week after the corners have healed", "dose_source": "Daktarin Sugar Free 2% Oral Gel SmPC sections 4.2-4.5 (eMC product 6597)", "rationale": "First-line topical antifungal with potent inherent Gram-positive antibacterial activity against staphylococci", "cautions": [ "Miconazole oral gel interacts significantly with oral anticoagulants (Warfarin) causing severe bleeding risk; avoid co-administration.", "Investigate underlying predisposing factors: ill-fitting dentures, iron deficiency anemia, B12/folate deficiency, diabetes.", "The oral gel is barred under 4 months, and at any age if the swallowing reflex is not fully developed. It has choked infants. Never put it at the back of the throat: divide the dose, smear it on with a clean finger, and watch the child.", "Continue a week past the point the corners look healed. Stopping the day they clear is why it returns.", "Avoid in liver dysfunction." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child >4 months: apply a thin layer of 2% oral gel to labial commissures 4 times daily after meals", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": 4.0, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "MICONOL 2% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DERMOZOL 2% GEL 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MICO ORAL 2% ORAL GEL 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 6.25, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BUCCAZOLE 2% ORAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MICONAZ 2% ORAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DAKTARIN 2% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > JANSSEN CILAG", "price_egp": 28.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DAKTARIN 2% ORAL GEL 40 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JANSSEN CILAG > SOFICOPHARM", "price_egp": 53.5, "pack_count": null, "unit_price": null, "strength_mg": 40000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADCOZOLE 2% TOPICAL CR. 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 7.25, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angular-cheilitis" }, { "id": 183, "generic": "Fusidic acid", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 2% topical cream to corners of mouth two to three times daily", "adult_duration": "7-10 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (fusidic acid monograph)", "rationale": "Topical antibacterial alternative when pure staphylococcal bacterial infection is suspected", "cautions": [ "Avoid prolonged or repeated courses to prevent bacterial resistance.", "Local skin hypersensitivity reactions may occur." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Apply small amount to affected area 2 to 3 times daily for 7 to 14 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FOSTINO 2% TOPICAL GEL 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ZAD", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANESTY 2% TOPICAL GEL 15GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI)", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUSIDIC ACID 2% GEL 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUSIDICTAM 2 % TOP. CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > MAGIC PHARMA-EGYPT", "price_egp": 26.5, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUCI-TOP 2% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HIKMA PHARMA", "price_egp": 44.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUCIDIN 2% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > LEO PHARMACEUTICAL PRODUCTS", "price_egp": 56.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUCIDIN 2% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > LEO PHARMACEUTICAL PRODUCTS", "price_egp": 96.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FUCIDIN 2% OINTMENT 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > LEO PHARMACEUTICAL PRODUCTS", "price_egp": 96.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angular-cheilitis" }, { "id": 184, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Angular Cheilitis - disease-level clinical article (angular-cheilitis-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Unilateral or treatment-refractory angular cheilitis raises concern for underlying malignancy or systemic nutritional deficiencies." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "angular-cheilitis" } ] }