{ "schema_version": 1, "kind": "condition", "id": "allergic-conjunctivitis", "name": "Allergic conjunctivitis", "category": "chronic", "sources": "AAO Preferred Practice Pattern: Conjunctivitis 2018 · Opatanol 1 mg/ml eye drops SmPC sections 4.2 and 4.4 (eMC product 6768) · eMC SmPC, Zaditen 0.25 mg/ml eye drops solution (Thea Pharmaceuticals), sections 4.1 and 4.2 · Allergic Conjunctivitis - disease-level clinical article (allergic-conjunctivitis-clinical.txt) · Egyptian National Drug Formulary - Respiratory System 2026 (loratadine monograph)", "review_status": "reviewed", "verified_against": "Opatanol 1 mg/ml eye drops SmPC sections 4.2 and 4.4 (eMC product 6768) · eMC SmPC, Zaditen 0.25 mg/ml eye drops solution (Thea Pharmaceuticals), sections 4.1 and 4.2 · Allergic Conjunctivitis - disease-level clinical article (allergic-conjunctivitis-clinical.txt) · Egyptian National Drug Formulary - Respiratory System 2026 (loratadine monograph)", "verified_date": "2026-08", "treatments": [ { "id": 129, "generic": "Olopatadine", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "1 drop into the affected eye(s) twice daily, 8 hours apart", "adult_duration": "as required", "dose_source": "Opatanol 1 mg/ml eye drops SmPC sections 4.2 and 4.4 (eMC product 6768)", "rationale": "Combines direct antihistamine blockade with mast cell stabilization, calming the immediate itching and redness of allergic conjunctivitis while also reducing further histamine release on continued allergen exposure.", "cautions": [ "Soft contact lenses take up the preservative and discolour: out before the drop, back in no sooner than 15 minutes after.", "Transient burning or stinging may occur upon drop instillation.", "Licensed from 3 years at the adult dose, and may be continued up to four months where needed.", "Olopatadine has dual antihistamine and mast cell stabilizer action." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >3 years: 1 drop twice daily into affected eye(s)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": 36.0, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Over 3 years", "age_min_months": 37, "age_max_months": 216, "dose_text": "1 drop into affected eye twice daily." } ], "peds_doses": null, "brands": [ { "trade_name": "PATADOLINE 0.1% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL ADVANCED PHARMACEUTICALS (GAP)", "price_egp": 38.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "allergic-conjunctivitis" }, { "id": 130, "generic": "Ketotifen", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "One drop of 0.25 mg/mL solution into the conjunctival sac of the affected eye(s) twice daily", "adult_duration": "Through the allergen season; the SmPC sets no maximum duration", "dose_source": "eMC SmPC, Zaditen 0.25 mg/ml eye drops solution (Thea Pharmaceuticals), sections 4.1 and 4.2", "rationale": "22 live products, and Egyptian ketotifen is sold in both oral and eye-drop form. The SmPC indication is symptomatic treatment of seasonal allergic conjunctivitis, which is this condition exactly, and the row currently holds only olopatadine.", "cautions": [ "Remove soft contact lenses before instilling and wait at least 15 minutes before reinserting - the benzalkonium chloride is absorbed by the lens material and discolours it.", "Each drop contains 2.6 micrograms of benzalkonium chloride, which can irritate a dry or damaged cornea.", "Transient blurring and drowsiness after instillation - do not drive until vision has cleared.", "Leave at least 5 minutes between this and any other eye drop.", "Pain, photophobia or reduced vision is not allergic conjunctivitis - refer.", "There are also oral ketotifen products in Egypt with the same generic name; those are a different treatment at a different dose and are sedating." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children aged 3 years and over: the same regimen as adults, one drop twice daily. Safety and efficacy below 3 years have not been established. No mg/kg dosing applies to eye drops.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "3 years and over", "age_min_months": 36, "age_max_months": 216, "dose_text": "One drop twice daily, the same regimen as adults" } ], "peds_doses": null, "brands": [ { "trade_name": "PROPHALLERGE 0.025% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOTISWIX 0.025% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REDNOTT 0.25MG/ML EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > PHAROPHARMA", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZADITEN 0.025% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EXCELVISION > NOVARTIS", "price_egp": 28.8, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORCHAZID 0.025% EYE DPS. 10 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 31.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORCHAZID 0.025% EYE DROPS 30*0.4 ML SDU", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "allergic-conjunctivitis" }, { "id": 131, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Allergic Conjunctivitis - disease-level clinical article (allergic-conjunctivitis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Pain and decreased visual acuity are not typical of simple allergic conjunctivitis; their presence should raise suspicion of an alternative (more serious) diagnosis rather than being treated as ordinary allergic conjunctivitis." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "allergic-conjunctivitis" }, { "id": 132, "generic": "Loratadine", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily", "adult_duration": "as-needed", "dose_source": "Egyptian National Drug Formulary - Respiratory System 2026 (loratadine monograph)", "rationale": "The disease article calls for an oral antihistamine in severe symptoms and prefers loratadine over diphenhydramine for its lower sedation.", "cautions": [ "Children under 2 years of age: safety and efficacy have not been established, no data are available.", "CrCl under 30 mL/minute: 10 mg every 48 hours", "Severe liver impairment: 10 mg every other day in adults and children over 30 kg, 5 mg every other day at 30 kg or less" ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "ENDF: 10 mg once daily from 6 years; 5 mg once daily from 2 to 6 years. By weight in children under 12: 5 mg once daily at 30 kg or less, 10 mg once daily above 30 kg.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": 24.0, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 to under 6 years", "age_min_months": 24, "age_max_months": 71, "dose_text": "5 mg once daily" }, { "label": "6 years and over", "age_min_months": 72, "age_max_months": 216, "dose_text": "10 mg once daily" } ], "peds_doses": null, "brands": [ { "trade_name": "HISTALONG 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 17.0, "pack_count": 20, "unit_price": 0.85, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UNILORATADINE 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 17.0, "pack_count": 20, "unit_price": 0.85, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEDCLARIT 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 19.5, "pack_count": 20, "unit_price": 0.97, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LORATADINE 10MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 25.5, "pack_count": 10, "unit_price": 2.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ONY 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 51.0, "pack_count": 20, "unit_price": 2.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALLERGETONE 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI) > SPLENDID PHARMA", "price_egp": 66.0, "pack_count": 20, "unit_price": 3.3, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLARITINE 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO > BAYER HEALTHCARE", "price_egp": 110.0, "pack_count": 20, "unit_price": 5.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALLERGIRAZ 10MG 30 DISINTEGRATING TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS > ELRAZY PHARMACEUTICALS-EGYPT", "price_egp": 31.5, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LORANO 5MG/5ML SYRUP 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "UNILORATADINE 5MG/5ML SYRUP 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "allergic-conjunctivitis" } ] }