{
  "schema_version": 1,
  "kind": "condition",
  "id": "adrenogenital-syndrome",
  "name": "Adrenogenital disorder",
  "category": "chronic",
  "sources": "Congenital Adrenal Hyperplasia - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK448098/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class TD99.02 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care · Congenital Adrenal Hyperplasia - StatPearls - NCBI Bookshelf (NBK448098)",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care · Adrenogenital disorder - disease-level clinical article (adrenogenital-syndrome-clinical.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 119,
      "generic": "Referral & safety-netting (no drug therapy)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Includes congenital adrenal hyperplasia and related virilising disorders; primary care recognises signs (ambiguous genitalia, early puberty, virilisation) and refers to paediatric endocrinology.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Includes congenital adrenal hyperplasia and related virilising disorders; primary care recognises signs (ambiguous genitalia, early puberty, virilisation) and refers to paediatric endocrinology.",
      "cautions": [
        "Salt-wasting congenital adrenal hyperplasia in a newborn is a life-threatening emergency needing urgent referral.",
        "Referral is the pathway; the medicines listed alongside are what primary care can give before or while it happens.",
        "RED FLAG - Adrenal crisis is the most common cause of mortality in CAH; patients must be educated on stress dosing, wear medical ID, and carry an emergency hydrocortisone injection kit."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "adrenogenital-syndrome"
    },
    {
      "id": 120,
      "generic": "Hydrocortisone",
      "line": 1,
      "is_adjunct": false,
      "form": "injection",
      "strength_mg": null,
      "adult_dose": "50 to 100 mg/m2 by intramuscular or intravenous injection, as a single stress dose",
      "adult_duration": null,
      "dose_source": "Congenital Adrenal Hyperplasia - StatPearls - NCBI Bookshelf (NBK448098)",
      "rationale": "A known CAH patient who is vomiting, febrile or injured can decompensate within hours, and the injection has to be given before transfer rather than after it. That is the one moment a GP has to act.",
      "cautions": [
        "Do not use it where there is known hypersensitivity to hydrocortisone or an untreated systemic infection.",
        "This is the emergency dose only. The daily replacement doses in congenital adrenal hyperplasia are set and adjusted by an endocrinologist and must not be started in the clinic.",
        "Give it alongside fluid resuscitation and arrange transfer; the injection alone does not treat the salt loss or the low blood sugar."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children get the same 50 to 100 mg/m2 stress dose; a newborn is given 25 mg, then 100 mg/m2 per day divided every 6 hours. Dosing here is by body surface area, not per kilogram.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "SOLU-CORTEF 100MG/2ML VIAL",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO > PFIZER",
          "price_egp": 16.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 100.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "HYDROCORTISONE SODIUM SUCCINATE 100MG I.V./I.M.VIAL",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 26.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 100.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "SIGMACORTIN 500MG PD. FOR I.M./I.V.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SIGMA-TEC > SIGMA",
          "price_egp": 34.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 500.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "adrenogenital-syndrome"
    }
  ]
}