{ "schema_version": 1, "kind": "condition", "id": "acute-rheumatic-fever-with-carditis", "name": "Acute rheumatic fever with carditis", "category": "chronic", "sources": "Acute Rheumatic Fever - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK459263/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class KD02.00 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care", "review_status": "reviewed", "verified_against": "No dose - referral pathway, no medicine given in primary care · Egyptian National Drug Formulary - Antimicrobial 2023", "verified_date": "2026-08", "treatments": [ { "id": 91, "generic": "No drug therapy in primary care (Referral & Advice)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": "Active rheumatic fever with carditis needs hospital-level monitoring (echocardiography, watching for heart failure); the GP recognises the picture, starts antibiotic treatment of the streptococcal trigger, and refers urgently rather than managing carditis alone.", "adult_duration": "Refer, with advice", "dose_source": "No dose - referral pathway, no medicine given in primary care", "rationale": "Active rheumatic fever with carditis needs hospital-level monitoring (echocardiography, watching for heart failure); the GP recognises the picture, starts antibiotic treatment of the streptococcal trigger, and refers urgently rather than managing carditis alone.", "cautions": [ "Breathlessness, tachycardia out of proportion to fever, or a new murmur indicates carditis severe enough to need same-day hospital assessment.", "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "acute-rheumatic-fever-with-carditis" }, { "id": 92, "generic": "Penicillin G benzathine", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": null, "adult_dose": "IM: 1.2 million units once every 21 to 28 days", "adult_duration": "Duration depends on risk factors and presence of valvular heart disease", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "Intramuscular penicillin G benzathine provides secondary prophylaxis against recurrent Group A streptococcal infection to prevent recurrent rheumatic fever and progressive cardiac damage.", "cautions": [ "Hypersensitivity to penicillin(s) or any component of the formulation", "Do not administer IV, intra-arterially, or SubQ. inadvertent IV administration has resulted in thrombosis, severe neurovascular damage, cardiac arrest, and death." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "≤27 kg: 600,000 units every 3 to 4 weeks. >27 kg: 1.2 million units every 3 to 4 weeks.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HAYA BENZ-R 1.2 M.I.U. VIAL FOR I.M INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO > HAYA PHARM-EGYPT", "price_egp": 5.06, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENICID LA 1 200 000 UNITS VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BENZACILLIN 1.2 M.I.U.FOR I.M.INJ VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RETARPEN 1.2 M.I.U. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ > OCTOBER PHARMA", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LASTIPEN 1 200 000 IU VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BENZABIOTIC 1.2 M.I.U. I.M. VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 16.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEPO-PEN 1.2 MIU VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 25.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENCILONG (PENCITARD) 1200000 I.U./VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NCPC NORTH BEST CO > ACDIMA INTERNATIONAL TRADING", "price_egp": 25.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-rheumatic-fever-with-carditis" } ] }