{ "schema_version": 1, "kind": "condition", "id": "acute-pericarditis", "name": "Acute Pericarditis", "category": "acute", "sources": "2015 ESC Guidelines for the diagnosis and management of pericardial diseases, European Society of Cardiology (Eur Heart J 2015;36:2921-64)", "review_status": "reviewed", "verified_against": "2015 ESC Guidelines for the diagnosis and management of pericardial diseases, European Society of Cardiology (Eur Heart J 2015;36:2921-64) · Acute Pericarditis - disease-level clinical article (acute-pericarditis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 78, "generic": "Ibuprofen", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "600 mg orally every 8 hours (1800 mg/day) for 1 to 2 weeks, guided by symptoms and CRP, then tapered (decrease dose by 200-400 mg every 1-2 weeks).", "adult_duration": "1 to 2 weeks, then tapered", "dose_source": "2015 ESC Guidelines for the diagnosis and management of pericardial diseases, European Society of Cardiology (Eur Heart J 2015;36:2921-64)", "rationale": "The guideline names aspirin or an NSAID as the mainstay of therapy for acute pericarditis, and gives ibuprofen at 1200-2400 mg/day with treatment duration guided by symptoms and CRP.", "cautions": [ "Confirm the diagnosis before treating: pleuritic chest pain relieved by sitting forward, a friction rub, widespread ST elevation or PR depression on ECG, or a pericardial effusion. Chest pain is not pericarditis until the alternatives are excluded.", "GASTROPROTECTION is part of the recommendation, not optional - the guideline states it should be provided with aspirin or an NSAID at these doses.", "Taper rather than stop abruptly; the guideline recommends tapering be considered.", "Rest matters and is the guideline's first non-drug recommendation: restrict activity beyond ordinary sedentary life until symptoms resolve and CRP normalises.", "Refer the same day if there is fever above 38C, a large effusion, tamponade, trauma, immunosuppression, anticoagulation, or a failure to respond after a week - these mark a poor prognosis.", "Rising troponin means myopericarditis, which is a different problem and needs cardiology." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The guideline is written for adults. Pericarditis in a child is a paediatric cardiology problem, not a primary-care dosing decision.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DAJUANOFEN 400 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLABU 400MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 3.75, "pack_count": 10, "unit_price": 0.38, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 400MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.75, "pack_count": 30, "unit_price": 0.42, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBUPROFEN 400 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAFO 400 MG 30 F.C.TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEN 400 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 78.0, "pack_count": 30, "unit_price": 2.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PROFUSOL 400MG 20 S.G CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 31.0, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANALGIPROF 400 MG 25 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 37.5, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 2.25, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEMOL-N SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "acute-pericarditis" }, { "id": 79, "generic": "Acetylsalicylic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "750-1000 mg every 8 hours for 1 to 2 weeks, then tapered. Preferred over an NSAID when the patient already needs aspirin, for example after a myocardial infarction", "adult_duration": "1 to 2 weeks, symptom and CRP guided", "dose_source": "2015 ESC Guidelines for the diagnosis and management of pericardial diseases, European Society of Cardiology (Eur Heart J 2015;36:2921-64)", "rationale": "The guideline names aspirin alongside NSAIDs as the mainstay of therapy. It is the anti-inflammatory of choice where antiplatelet treatment is wanted anyway, since an NSAID would otherwise be added on top of it.", "cautions": [ "Sold in Egypt as acetylsalicylic acid - aspirin is the common name, not the register name.", "This is anti-inflammatory dosing, several times the antiplatelet dose - do not confuse it with 75-150 mg once daily.", "GASTROPROTECTION is part of the recommendation at this dose.", "Confirm the diagnosis before treating: pleuritic chest pain relieved by sitting forward, a friction rub, widespread ST elevation or PR depression on ECG, or a pericardial effusion. Chest pain is not pericarditis until the alternatives are excluded.", "Taper rather than stop abruptly.", "Acetylsalicylic acid is not for children - there is a risk of Reye's syndrome." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "NOT for children. Aspirin in a child carries the risk of Reye's syndrome, and paediatric pericarditis is a cardiology problem in any case.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ASPOCID 300 MG 200 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 80.0, "pack_count": 200, "unit_price": 0.4, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AGGREX 75MG 60 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 33.0, "pack_count": 60, "unit_price": 0.55, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPOCID 75MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 22.0, "pack_count": 20, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECOPRIN 325MG 10 ENTERIC COATED TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 325.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIVO 75 MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPRICARLO 81MG 30 CHEWABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 45.0, "pack_count": null, "unit_price": null, "strength_mg": 81.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPIRIN PROTECT 100 MG 30 GASTRO-RESISTANT TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS > BAYER BITTERFELD GMBH-GERMANY", "price_egp": 78.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "JUSPRIN 81 MG 60 E.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > JULPHAR", "price_egp": 81.0, "pack_count": null, "unit_price": null, "strength_mg": 81.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-pericarditis" }, { "id": 81, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Pericarditis - disease-level clinical article (acute-pericarditis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - The admission criteria for poor prognostic markers are fever >38°C, subacute/recurrent presentation, large effusion, cardiac tamponade, or failure to respond within 1 week." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "acute-pericarditis" }, { "id": 80, "generic": "Colchicine", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 0.5, "adult_dose": "0.5 mg ONCE daily if under 70 kg, or 0.5 mg TWICE daily if 70 kg or over, for 3 months. After a recurrence the guideline's trials used 6 months", "adult_duration": "3 months (6 months after a recurrence)", "dose_source": "2015 ESC Guidelines for the diagnosis and management of pericardial diseases, European Society of Cardiology (Eur Heart J 2015;36:2921-64)", "rationale": "The guideline recommends colchicine as first-line therapy in addition to aspirin or an NSAID, at low weight-adjusted doses. It is what reduces recurrence, which is the main problem in this condition - so it is an add-on to the anti-inflammatory, never a replacement for it.", "cautions": [ "GIVE IT WITH THE ANTI-INFLAMMATORY, NOT INSTEAD OF IT. It is what cuts the recurrence rate, and recurrence is the main problem in pericarditis.", "The dose is weight-split at 70 kg: 0.5 mg once daily under 70 kg, 0.5 mg twice daily at 70 kg and over. It is NOT the gout regimen.", "Egypt's commonest colchicine tablet is 1 mg, so the 0.5 mg dose usually means half a tablet; 500 microgram and 0.6 mg tablets are also registered.", "The colchicine product label does not carry pericarditis - it covers gout and familial Mediterranean fever. This dose is from the ESC guideline, not the licence.", "Reduce or avoid in significant renal or hepatic impairment, and it interacts dangerously with clarithromycin and with statins. Colchicine 500 microgram tablets SmPC (https://www.medicines.org.uk/emc/product/100968), s4.5: \"Colchicine is contraindicated in patients with renal or hepatic impairment who are taking a P-gp inhibitor ... or a strong CYP3A4 inhibitor (e.g. ritonavir, atazanavir, indinavir, clarithromycin, telithromycin, itraconazole or ketoconazole)\"; and \"The risk of myopathy and rhabdomyolysis is increased by a combination of colchicine with statins, fibrates, ciclosporin or digoxin.\"", "Diarrhoea is the usual reason it is stopped; it is dose-related.", "Confirm the diagnosis before treating: pleuritic chest pain relieved by sitting forward, a friction rub, widespread ST elevation or PR depression on ECG, or a pericardial effusion. Chest pain is not pericarditis until the alternatives are excluded." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The guideline is written for adults and does not dose children for this indication.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "COLCHICINE 500 MCG 100 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 190.0, "pack_count": 100, "unit_price": 1.9, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COLMEDITEN 0.5 MG 100 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 190.0, "pack_count": 100, "unit_price": 1.9, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GOURYST 0.5 MG 100 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 190.0, "pack_count": 100, "unit_price": 1.9, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-pericarditis" } ] }