{ "schema_version": 1, "kind": "condition", "id": "acne-vulgaris", "name": "Acne vulgaris (mild-to-moderate)", "category": "chronic", "sources": "Spironolactone tablets US prescribing information, sections 2.3 and 3 (DailyMed SetID c23b6b9b-aec3-48a8-a518-76e4097f6479, Sun Pharmaceutical Industries): \"Hypertension: Initiate treatment at 25 to 100 mg daily in either single or divided doses\" and \"Tablets: 25 mg, 50 mg, and 100 mg\". The 25 to 100 mg range and the divided-dose option are the label's; the label carries no acne indication, so the acne use is off-label. · ADAPALENE US prescribing information, Dosage and Administration (DailyMed SetID 330bc2b3-e064-4189-9c47-9c5a50aa4dde) · Acnecide 5% w/w Gel SmPC section 4.2 (eMC product 2225) · CLINDAMYCIN PHOSPHATE US prescribing information, Dosage and Administration (DailyMed SetID 96434354-a646-4869-92a2-4052d3f7a4aa) · NICE Guideline NG198 (2021), recommendation 1.5.1 · NICE Guideline NG198 (2021), recommendation 1.5.12; NICE Guideline NG198 Acne vulgaris: management (2023 update), recommendation on treatments not to use (NCBI Bookshelf niceng198guid) · Skinoren 20% Cream SmPC sections 4.1 and 4.2 (eMC product 285) · UK eMC Doxycycline 100mg Capsules SmPC (or DailyMed Doxycycline 100mg Capsule Package Insert) · eMC SmPC, Roaccutane 10 mg soft capsules (Neon Healthcare), sections 4.1 and 4.2", "review_status": "reviewed", "verified_against": "Spironolactone tablets US prescribing information, sections 2.3 and 3 (DailyMed SetID c23b6b9b-aec3-48a8-a518-76e4097f6479, Sun Pharmaceutical Industries): \"Hypertension: Initiate treatment at 25 to 100 mg daily in either single or divided doses\" and \"Tablets: 25 mg, 50 mg, and 100 mg\". The 25 to 100 mg range and the divided-dose option are the label's; the label carries no acne indication, so the acne use is off-label. · ADAPALENE US prescribing information, Dosage and Administration (DailyMed SetID 330bc2b3-e064-4189-9c47-9c5a50aa4dde) · Acnecide 5% w/w Gel SmPC section 4.2 (eMC product 2225) · CLINDAMYCIN PHOSPHATE US prescribing information, Dosage and Administration (DailyMed SetID 96434354-a646-4869-92a2-4052d3f7a4aa) · NICE Guideline NG198 (2021), recommendation 1.5.1 · Skinoren 20% Cream SmPC sections 4.1 and 4.2 (eMC product 285) · UK eMC Doxycycline 100mg Capsules SmPC (or DailyMed Doxycycline 100mg Capsule Package Insert) · eMC SmPC, Roaccutane 10 mg soft capsules (Neon Healthcare), sections 4.1 and 4.2 · Acne Vulgaris - disease-level clinical article (acne-vulgaris-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 22, "generic": "Adapalene", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 0.1% gel or cream thin layer once daily to clean skin at bedtime", "adult_duration": null, "dose_source": "ADAPALENE US prescribing information, Dosage and Administration (DailyMed SetID 330bc2b3-e064-4189-9c47-9c5a50aa4dde)", "rationale": "First-line topical retinoid targeting comedones and inflammation", "cautions": [ "Local irritation, erythema, and peeling are common during the first 2-4 weeks.", "Apply sunscreen during day (increases photosensitivity).", "If pregnant or breast-feeding, ask a doctor before use." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >12 years: apply thin layer once daily at bedtime", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ADANOID 0.1% TOP. GEL 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ACNE-JED 0.1% TOPICAL GEL 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 16.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PAL-MASH 0.1% TOPICAL CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > MASH PREMIERE", "price_egp": 16.5, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADAGEL 0.1% TOPICAL GEL. 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > TAG PHARMA", "price_egp": 34.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADAPALENE 0.1% GEL 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 34.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MARPALENE 0.1% TOPICAL CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI)", "price_egp": 34.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RANDAPALENE 0.1% GEL 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > REXCEL", "price_egp": 38.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AKNAPALEN 1% TOPICAL GEL 25 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 34.0, "pack_count": null, "unit_price": null, "strength_mg": 25000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 23, "generic": "Benzoyl peroxide", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 5% gel once or twice daily after washing", "adult_duration": null, "dose_source": "Acnecide 5% w/w Gel SmPC section 4.2 (eMC product 2225)", "rationale": "Topical antimicrobial with comedolytic action and no bacterial resistance", "cautions": [ "Bleaches hair, clothing, and bed linen on contact.", "Start with 2.5% or 5% strength to minimize skin irritation.", "Avoid contact with eyes, lips, and mucous membranes.", "5% is the only strength on the Egyptian register - Akneroxid-5 and Panoxyl 5%. No Egyptian pharmacy stocks a 2.5% single-agent gel. Start on alternate days if the skin is irritable; 5% is not gentler than 2.5% and bleaches fabric." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >12 years: apply 2.5-5% gel once or twice daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AKNEROXID-5 5% GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > HERMAL-GERMANY", "price_egp": 4.25, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PANOXYL 5% GEL 40 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > STEIFEL LABORATORIES U.K LTD", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 40000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 26, "generic": "Azelaic acid", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 20% cream thinly twice daily, morning and evening, to clean dry skin; about 2.5 cm of cream covers the whole face", "adult_duration": null, "dose_source": "Skinoren 20% Cream SmPC sections 4.1 and 4.2 (eMC product 285)", "rationale": "NG198 names topical azelaic acid as one of the five first-line options. It matters in Egypt because it does not bleach clothing the way benzoyl peroxide does, it is far less irritating than a retinoid, and it fades the post-inflammatory pigmentation that darker skin is left with - which is often what the patient actually minds.", "cautions": [ "Patients with sensitive skin should use it once daily in the evening for the first week, then move to twice daily.", "Burning, stinging and itching in the first 2-4 weeks are expected and settle; warn the patient or they will stop.", "Improvement takes about 4 weeks to become apparent and the course is 12 weeks - the commonest failure is stopping at 3 weeks.", "The label says caution should be exercised when prescribing azelaic acid to pregnant women. Unlike the retinoids it is not contraindicated, which makes it the practical choice in a pregnant patient with acne.", "Keep it away from eyes, mouth and other mucous membranes.", "Per NG198 it is used with an oral antibiotic for moderate to severe acne, not as a standalone for that severity." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No dose adjustment for adolescents aged 12 to 18. Safety and efficacy have not been established under 12 years.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "12 to 18 years", "age_min_months": 144, "age_max_months": 216, "dose_text": "The adult application, with no dose adjustment." } ], "peds_doses": null, "brands": [ { "trade_name": "AZECLEAR 20% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIOPHARM EGYPT > SAJA PHARMA", "price_egp": 21.6, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EZALIC 20% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 26.4, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SKINOREN 20% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTENDIS MANUFACTURING SPA-ITALY > BAYER HEALTHCARE", "price_egp": 35.5, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZADERM 20% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 87.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 28, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Acne Vulgaris - disease-level clinical article (acne-vulgaris-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Dermatologist referral is recommended for severe acne.", "RED FLAG - Acne fulminans (systemic symptoms - fever, bone pain, ulcerating/hemorrhagic lesions) requires urgent lab workup, not seen among app treatments/cautions" ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "acne-vulgaris" }, { "id": 24, "generic": "Clindamycin", "line": 2, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 1% solution or gel thin layer BID (always combine with BPO or retinoid)", "adult_duration": null, "dose_source": "CLINDAMYCIN PHOSPHATE US prescribing information, Dosage and Administration (DailyMed SetID 96434354-a646-4869-92a2-4052d3f7a4aa)", "rationale": "Topical antibiotic for inflammatory acne; must combine to prevent resistance", "cautions": [ "Do NOT use as monotherapy (high risk of bacterial resistance).", "Always co-prescribe with benzoyl peroxide.", "Discontinue if severe diarrhea develops." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >12 years: apply 1% gel BID for max 12 weeks", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CLINDACINE RAMEDA 1% TOPICAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINOCID 1% TOPICAL CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDASOL 1% TOPICAL GEL 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA > EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 25, "generic": "Isotretinoin", "line": 4, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "0.5 mg/kg daily initially, adjusted within the range 0.5-1.0 mg/kg/day to a cumulative total of 120-150 mg/kg", "adult_duration": "16-24 weeks typically achieves remission; there is no substantial additional benefit beyond a cumulative 150 mg/kg", "dose_source": "eMC SmPC, Roaccutane 10 mg soft capsules (Neon Healthcare), sections 4.1 and 4.2", "rationale": "20 live products, oral and topical. The only acne condition in the dataset, and a search for isotretinoin currently returns nothing at all even though it is the single most consequential acne drug a GP will encounter on a patient's prescription.", "cautions": [ "THIS CONDITION IS MILD-TO-MODERATE ACNE AND ORAL ISOTRETINOIN IS NOT FOR THAT. The licensed indication is severe nodular or conglobate acne, or acne at risk of permanent scarring, that has resisted adequate courses of systemic antibacterial plus topical therapy.", "Must be prescribed only by, or under the supervision of, a physician experienced in systemic retinoid therapy.", "PREGNANCY PREVENTION PROGRAMME is mandatory for any woman able to become pregnant: highly effective contraception from one month before, throughout, and one month after treatment, with monthly pregnancy testing.", "Depression, anxiety, aggression, mood change, psychotic symptoms and suicide have been reported - assess mental health before starting and at every review, and ask the family.", "Check serum lipids and liver enzymes at baseline, at one month, then quarterly; stop for uncontrolled hypertriglyceridaemia or pancreatitis symptoms.", "Do not co-prescribe a tetracycline - benign intracranial hypertension. That rules out the doxycycline commonly used in acne.", "Do not donate blood during treatment or for one month afterwards.", "Topical isotretinoin and tretinoin products share the generic name but are an entirely different treatment with none of these requirements." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Must not be used for prepubertal acne and is not recommended under 12 years. In an adolescent 12 years and over the adult mg/kg regimen applies, under dermatology supervision. The mg/kg fields are left null because the paediatric dose is not a separate figure - it is the same 0.5-1.0 mg/kg/day, which is captured in the adult dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ROACCUTREX 20 MG 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > EGYPHARMA-EGYPT", "price_egp": 161.0, "pack_count": 30, "unit_price": 5.37, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISO-ACNETIN 20 MG 30 CAPS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > GLOBE TECH PHARMACEUTICALS", "price_egp": 300.0, "pack_count": 30, "unit_price": 10.0, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ACNELOFIX 20 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MELANO PHARMA", "price_egp": 270.0, "pack_count": 20, "unit_price": 13.5, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ROACCUTANE 20 MG 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "F.HOFFMAN LA ROCHE", "price_egp": 533.0, "pack_count": 30, "unit_price": 17.77, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOTRETINOIN 20MG 10 SOFT GELATIN CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RANBAXY", "price_egp": 124.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOTRETAM 20 MG 20 S.G. CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN", "price_egp": 212.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NETLOOK 20MG 20 SOFT GELATIN CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > ANDALOUS PHARMA", "price_egp": 274.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOTRETINOIN 20MG 30 SOFT GELATIN CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SUN PHARMA EGYPT LIMITED > RANBAXY", "price_egp": 372.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 27, "generic": "Doxycycline", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg once daily with food or fluid", "adult_duration": "12 weeks, reviewed at 12 weeks; a further 12 weeks only if the acne has improved but not cleared", "dose_source": "NICE Guideline NG198 Acne vulgaris: management, \"Terms used in this guideline\", entry \"Oral lymecycline or oral doxycycline\": \"Formulation of either: 408 mg lymecycline daily / 100 mg doxycycline daily.\" The UK eMC Doxycycline 100mg Capsules SmPC section 4.2 states a lower figure for the same indication - \"50 mg daily with food or fluid for 6 to 12 weeks\" - and the DailyMed doxycycline capsule label states no acne dose at all, only that in severe acne doxycycline \"may be useful adjunctive therapy\". Under the tier list in docs/SOURCES.md a tier-1 guideline outranks a tier-2 product label for a dose, so NG198 leads and the label figure is recorded here.", "rationale": "Lymecycline is the other tetracycline NG198 names and it is not marketed in Egypt; doxycycline is, in 12 products. Moderate-to-severe acne needs an oral antibiotic on top of the topicals and this condition had none between topical clindamycin and oral isotretinoin - a jump from a topical to a pregnancy-category-X specialist drug with nothing in between.", "cautions": [ "NICE NG198 rules out three things in acne: do not give a topical antibiotic on its own, do not give an oral antibiotic on its own, and do not pair a topical antibiotic with an oral one. So this is given alongside a topical retinoid with benzoyl peroxide, or alongside azelaic acid - never by itself, and never together with the topical clindamycin listed here.", "NEVER alone, and never with the topical clindamycin in this condition. NG198 1.5.11 forbids oral antibiotic monotherapy and forbids combining a topical antibiotic with an oral one.", "Contraindicated in pregnancy and when planning a pregnancy - discuss contraception before writing it.", "Do not co-prescribe with oral isotretinoin - the combination causes benign intracranial hypertension.", "Swallow upright with a full glass of water and not at bedtime, or the capsule ulcerates the oesophagus.", "Photosensitivity is a real problem in Egyptian sun over a 12-week course; advise sunscreen and cover.", "Review at 12 weeks. If the acne has completely cleared, stop the antibiotic and continue the topical.", "NG198 keeps its doses in the glossary and table 1 rather than in a numbered recommendation. 1.5.12 is the one that carries the 12-week review given here." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric acne dose is stated in the sources held for this drug. Doxycycline must not be given under 8 years: the eMC Doxycycline 100mg Capsules SmPC section 4.2 states it \"should not be used in children aged younger than 8 years due to the risk of teeth discolouration\". The 50 mg acne figure in that label is an adult and adolescent indication, not a child dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" }, { "id": 29, "generic": "Spironolactone", "line": 3, "is_adjunct": true, "form": "oral.solid", "strength_mg": null, "adult_dose": "Start at 25 or 50 mg daily. The dose may then be raised to a ceiling of 100 mg per day, taken all at once or split across 2 doses.", "adult_duration": null, "dose_source": "Spironolactone tablets US prescribing information, sections 2.3 and 3 (DailyMed SetID c23b6b9b-aec3-48a8-a518-76e4097f6479, Sun Pharmaceutical Industries): \"Hypertension: Initiate treatment at 25 to 100 mg daily in either single or divided doses\" and \"Tablets: 25 mg, 50 mg, and 100 mg\". The 25 to 100 mg range and the divided-dose option are the label's; the label carries no acne indication, so the acne use is off-label.", "rationale": "Oral anti-androgen therapy reducing sebum secretion by blocking androgen receptors for female patients with moderate-to-severe acne.", "cautions": [ "Adverse effects include hyperkalemia, breast tenderness, menstrual irregularities, orthostatic hypotension, and headache.", "Contraindicated in pregnancy due to risk of feminization of male fetus." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "SPIRONOLACTONE (DELTA) 25MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > AL DELTA PHARMACEUTICALS TRADING CO.", "price_egp": 3.0, "pack_count": 10, "unit_price": 0.3, "strength_mg": 25.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPILACTONE 25MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 4.0, "pack_count": 10, "unit_price": 0.4, "strength_mg": 25.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SPIRONOLACTONE (DELTA) 50MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > AL DELTA PHARMACEUTICALS TRADING CO.", "price_egp": 4.5, "pack_count": 10, "unit_price": 0.45, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SPIRONOLACTONE (DELTA) 100MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > AL DELTA PHARMACEUTICALS TRADING CO.", "price_egp": 16.8, "pack_count": 20, "unit_price": 0.84, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "POTASAVE 100 MG 20 TAB", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 21.0, "pack_count": 20, "unit_price": 1.05, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "POTASPIRONO 25 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 36.0, "pack_count": 20, "unit_price": 1.8, "strength_mg": 25.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "POTASPIRONO 100 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 90.0, "pack_count": 20, "unit_price": 4.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SPECTONE 100 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 90.0, "pack_count": 20, "unit_price": 4.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acne-vulgaris" } ] }